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1894;65:899-910.[DOI] 3

Too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally rapid heartbeat

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Treatment strategies can be categorized based on their targets, including the disruption of excitotoxicity, management of oxidative stress and mitochondrial dysfunction, treatment of inflammation and abnormal immune responses, modulation of glial cells, and the use of gene and stem cell therapies