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The use of the nomogram should be avoided until 4 h or more after ingestion as the levels may be misleading during this timeframe from the point of acute ingestion and not be an accurate predictor of toxicity[64,65]

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doi: 10.1111/j.1365-2125.2010.03743.x

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The doses were chosen in order to monitor autoprotection across a range of sub-toxic, threshold toxic and overtly toxic doses of APAP, to ensure that the drug exposure is relevant to what may occur in humans

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