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Skin aging profoundly impacts individuals appearance and causes significant physical and psychological distress

Similarly high incidence has been recently reported in Chinese provinces south of the Yangtze River (Figure 2), including Guangdong, Fujian, Hunan, Shanghai and Xuzhou in Zhejiang.7-10 In fact, the highest incidence of CUD may be in Fujian at around 1 in 10,000 newborns.9 On the other hand, incidence was lower in Northern China, like Shangdong.11 The high disease incidence in this locality is due to common mutations

Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) induces the expression of SLC7A11 in a transcriptional enhanced associate domain (TEAD)-dependent manner

Tyrosine modification by reactive nitrogen species: a closer look