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Description

This system mediates neuroprotection, synaptogenesis, cerebral blood flow, long-term potentiation and memory consolidation and retrieval

retatrutide adds a dose-dependent heart-rate signal and the highest adverse-event burden in indirect analyses

Pregnancy and breastfeeding are also contraindicated due to a lack of safety data for systemic use in these populations

Earlier Phase 2 monotherapy work also studied higher weekly doses up to 4.5 mg, but the cagrilintide-only schedule above matches the 2.4 mg weekly target shown throughout this page