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In addition, NRF2 also regulates the expression of ferritin subunits to promote free Fe 2+ sequestration, which can inhibit Fe 2+ -dependent free radical generation, and thus reducing the Fe 2+ -mediated toxicity [36]

(1) Ionescu M, Frohman LA (2006) Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog J Clin Endocrinol Metab