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To investigate the interaction between daunorubicin and ions further, we conducted a 100 ns CG-MD simulation of daunorubicin in pure water (S 2 ), copper glucose salt (S 2a ), Cu 2+ (S 2b ) and glucose (S 2c ), respectively

Oxidative stress inhibits mTOR through intermolecular disulfide bond formation with deptor in cardiomyocytes

Intriguingly, leptin deficiency is linked to the early-onset of obesity, indicating that ratio of leptin to insulin is fundamental in the homeostatic balance of fat and glucose metabolism (Wabitsch et al., 2015)