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D treatment, there were 21 DEGs and one DEM related to the AsAGSH cycle, four DEGs related to carotenoid biosynthesis, and 30 DEGs and five DEMs related to flavonoid biosynthesis, From these results, it was observed that the numbers of DEGs and DEMs regulated by the combination of G5 and Si were the highest and that their regulatory effects were more diverse ( Figure 6C )

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These factors collectively reprogram astrocytes to secrete additional neurotoxic mediators, further amplifying neuroinflammatory responses [357]

NAC was dosed at 200 or 300 mg/kg via intraperitoneal injection at 1 h after treatment with 600 mg/kg APAP