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Harmonic restraints of 50.0 kcal mol 1 2 were applied to the solutes, including the crystallographic ions, to allow solvent relaxation while preserving the maximum fidelity to the docking pose, and the Andersen temperature coupling scheme 81,82 was used to control and equalize the temperature

Instead, these findings provide novel evidence to suggest folate genotypes are selected to maintain homeostasis between de novo thymidylate synthesis and methylation processes at differing UVR levels

Standard thyroid testing, which is commonly available in the UK through the NHS and private health insurance is usually limited to: TSH Free T4 The TSH is produced by the pituitary (in the brain) and acts as a signal to the thyroid gland