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The Beaver Dam Eye Study [81] in the United States, the Blue Mountains Eye Study [82] in Australia, and the Barbados Eye Study [39] in Barbados are population-based cohort studies that have evaluated the possibility that cataracts may be a complication of myopia

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Similarly, a pegylated recombinant S1P lyase inhibitor designed to elevate sphingosine-1-phosphate systemically has entered phase I testing as a chemo-fertoprotectant