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Altogether, OVT has the potential to synergize the efficacy of CAR T cells in solid tumors by spreading TAA upon the direct lytic effect on tumor cells which prevents antigen loss, reversing the tumor-mediated immunosuppression, which improves CAR-T cell persistence in the tumor microenvironment, and arming with potent therapeutic molecules like chemokines [45]

Lomustine, chemically known as chloroethyl-cyclohexyl-nitrosourea (CCNU), is a monofunctional alkylating agent that is also a standard drug for GBM

10.1111/j.1365-2036.2011.04624.x 222

To ensure an overlap between the dosing period of dexamethasone and the risk period of fluoroquinolone-induced tendinopathy, we first assessed the data of dexamethasone prescribed before fluoroquinolone