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Commercial availability is anticipated in 2026 at the earliest

Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis

CagriSema is a fixed-dose combination of a long-acting amylin analogue, cagrilintide 2.4 mg and semaglutide 2.4 mg

Mechanistically, it upregulates VEGFR2 signalling, stimulates angiogenesis and fibroblast proliferation, and modulates the inflammatory cytokine response [3]