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In certain embodiments, the viscosity enhancing agents or viscosity modulating agents described herein are also utilized as the gelling agent for the gel formulations presented herein

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Effective anti-settling strategies include post-treatment with wax (reduces particle density and adds hydrophobicity), incorporating rheology modifiers like fumed silica at 0.30.5%, and optimizing the D50 to stay below 8 m where Brownian motion partially counteracts sedimentation

9 High-efficacy therapies: Balancing risk and benefit Biogens recombinant humanized monoclonal antibody, natalizumab (TYSABRI), mediates lymphocyte and monocyte cell adhesion and transendothelial migration via the 41 integrin pathway