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Methylation is vital to life as we know it, controlling many important functions such as epigenetic control of gene transcription,[1] production of adenosine triphosphate (ATP)[2] and detoxification.[3] Vitamins B2, B6, B12 and folate, as well as the amino acid serine, are highly efficient at enhancing methylation reactions throughout the body, and can provide assistance to facilitate effective methylation in those with known polymorphisms.[4] Figure 1: Five functional categories of methylation (energy production, phospholipid synthesis, cell signalling, cell maintenance, epigenetic modification)