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M., O'Rourke, B., Paolocci, N., Cortassa, S

This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)

About 85% of lung cancers are associated with smoking, however, lung cancer occurs also among non-smokers and represents the seventh most common cause of cancer mortality which indicates that other factors such as genetic predisposition, diet, silica, asbestos, high energy radiation, concentration of radon and other factors play a role

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