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Description

DA-depleting agents and DA receptor antagonists effectively reduced abnormal movements in patients with HD 3,4 , demonstrating the contribution of DA to motor dysfunction

C., Kok, F

2005 Nov;73(5):397-404

Conversely, out of 2000 PD cases, only 0.05% had mutations in the SNCA gene, creating uncertainty about how Syn accumulates in the other 99.95% of cases and whether the protein has a causative role in PD [62]