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Importantly, the possibility of evoking an adaptive immune response is one of the requisites to plan ICI therapy, and the identification of neoantigens or TAA together with antigen-specific TIL justify the cost of the treatment and predict, at least in principle, the response (183)

This article walks through three things in order: the no-human-data reality and what preclinical work does and doesn't establish, the theoretical oncological concern tied to the HGF/c-Met pathway, and the anecdotal adverse effects community sources describe