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Peripartal treatment with low-dose sertraline accelerates mammary gland involution and has minimal effects on maternal and offspring bone

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DNA methylation dynamically regulates gene expression profiles that dictate osteogenesis, adipogenesis, and immunomodulatory functions, thereby affecting stem cell fate and function ( In the realm of bone disease, abnormal DNA methylation patterns have been associated with pathological conditions such as osteonecrosis of the femoral head, where alterations in methylation influence MSC differentiation, angiogenesis, and osteocyte viability, underscoring the therapeutic potential of targeting DNA methylation to mitigate bone degeneration ( Mechanistically, DNA methyltransferases (DNMTs), including DNMT3A and DNMT3B, preserve methylation patterns crucial for stem cell commitment and differentiation